So right now I have 125mg of 1,3D coursing through my system (taking 5 pills spaced an hour apart to gague my response), and quite frankly, I'm sorry I didn't take the plunge and try it earlier. I was originally scared off by the lack of public, recent research done on 1,3D determining its pharmacokinetics. Hopefully Ely Lilly ruled out any sort of liver or kidney toxicity before attempting to market this drug from 1945-1971. I imagine they did, as the blue-light underground hasn't turned up any information to that effect.
My qualitative report on this is that it's a more centrally acting adrenergic than ephedra. Unlike caffeine, ephedra, or yohimbe alkaloids, this substance seems to stimulate norepinephrine-mediated inhibitory pathways in the brain. Now I've only heard of D2-type and prefrontal D1-type dopamine receptors having this function, as far as catecholamines are concerned. If there aren't any dopaminergic properties to 1,3D, then perhaps norepinephrine release in certain parts of the brain enhance focus and impulse control. I am trying to taper off a horrendously high daily dose of caffeine. Blame graduate school, that's when I felt the need to really push it. As a result, I've been morbidly tired, as close to narcoleptic as I've ever been. My adenosine levels must be really elevated! I've noticed that 1,3D doesn't slay the need to sleep like an unhealthy dose of caffeine does. It's more of a eugeroic. I remember taking Adrafinil a couple years ago, and 1,3D seems somewhat similar to it. Unlike dextroamphetamine or methylphenidate preparations, 1,3D doesn't trash one's ability to socialize, trash one's mood, or make one hyperfocus.
This is the bottom-line effect for me: enhanced focus, increased appetite, more long-term physical endurance as opposed to a jittery-legged, peripheral surge of energy. |
[4 of 5 Stars!]
