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Complete Diet Aid
Stack
$58.00
(1 customer review)
The Complete Diet Aid is a combination of supplements used to lose body fat while retaining lean mass. This stack has become very popular over the last year, and many users report exceptional results. Each ingredient serves a purpose, and many of them are synergistic. In addition to the effect on body composition, this stack offers many other possible benefits, such as improved mood, concentration, and general health. This article will briefly outline the benefits of each ingredient, as well as their combinations.
Acetyl-L-carnitine
Acetyl-L-carnitine (ALCAR) is the acetylated version of the amino acid L-carnitine, and is similar in effect, although many believe it to be superior. Oral administration of ALCAR causes pronounced fat loss and/or lean mass gain in animals, presumably by increasing the oxidation of fatty acids [1]. In healthy women, only 700 milligrams of L-carnitine, along with choline, caused a ~1% decrease in body fat level over 35 days compared to placebo and also increased fat utilization during exercise [2]. As an added benefit, L-carnitine also improves exercise performance in individuals with impaired exercise tolerance and improved markers of recovery after resistance training in healthy individuals [3-8]. ALCAR is also considered to be a potent brain nutrient, showing a multitude of beneficial effects on the brains of both young and old rats, and it has been used in the treatment Alzheimer's and Parkinson's [9-15]. Studies in humans with cardiovascular diseases have also found L-carnitine to have a profound impact on survival rate and other cardiovascular variables [16-19].
Alpha lipoic acid
Alpha lipoic acid (ALA) is a potent antioxidant and glucose disposal agent. As an antioxidant, ALA may protect against possible pro-oxidant properties of CLA and ALCAR [20-21]. ALA is also synergistic with ALCAR in improving cognitive function [11]. In combatting exercise-induced oxidative stress, ALA has been shown to be a superior antioxidant, and this in turn may improve skeletal muscle insulin sensitivity [22-23]. Like ALCAR, ALA also has strong cardioprotective properties [24-25].
Conjugated linoleic acid
Conjugated linoleic acid (CLA) is a unique omega-6 fatty acid (or rather, group of fatty acids) and weight loss aid. CLA interacts with a variety of enzymes which in turn increase lipolysis and downregulate lipogenesis [26-27]. Oral CLA administration has been found to cause fat loss in mice, hamsters, rats, chickens, dogs, and pigs, and in three trials in humans [26-27]. CLA is also an effective anti-carcinogen, and inhibits a variety of cancer types in experimental animals [27-29]. There are some possible side effects of CLA, such as increased insulin resistance, lipid peroxidation, and liver steatosis [26-27], but these should be more than counteracted by the other ingredients in the stack, many of which will prevent or reverse these conditions [24, 30-32].
Biotin
Biotin serves multiple purposes in this stack. Because it is structurally similar, ALA may reduce biotin stores [33], so supplemental biotin is included to protect against this. Increasing dietary biotin also helps prevent liver steatosis in animals [35], but it is unknown whether or not it would make a difference if the state was CLA-induced. Finally, biotin may act as another insulin sensitizing agent via induction of glucokinase synthesis [34].
Green tea
Green tea, the final ingredient in the stack, offers a multitude of benefits. Studies indicate that green tea leads to a significant increase in energy expenditure and weight loss in humans, and this effect is much larger than that which can be attributed to the caffeine alone [36-37]. This is because green tea inhibits the enzyme catechol-O-methyl-transferase (COMT), which in turn causes an increase in lipolytic hormone levels [36-38]. Like CLA, green tea has strong anti-cancer properties, and high intake of green tea has been associated with an increase in lifespan of 3.8-7.6 years [39]. EGCG, widely regarded as the most active ingredient in green tea, is another potent antioxidant, and green tea improves plasma antioxidant capacity in healthy humans [40-41]. Green tea also offers a significant improvement in cardiovascular health [39].
Suggested dosage and use
Acetyl-L-carnitine
:
1-2 capsules 2-3 times daily (1-3 g daily)
Biotin
:
1 capsule daily at any time (5 mg daily)
CLA
:
1-4 softgels 2 times daily with meals (2-8 g daily)
Green tea extract
:
3-6 capsules or more daily (1200+ mg daily)
R-ALA
:
1-3 capsules before and after each workout (200-600 mg daily)
For more in-depth information on the ingredients, see these articles:
ALA Information
Biotin and Health
Conjugated Linoleic Acid
Green Tea
L-Carnitine Description
If you have any questions or comments regarding this article, please email
dvdtlsn@bulknutrition.com
.
References
1. Iossa S, Mollica MP, Lionetti L, Crescenzo R, Botta M, Barletta A, Liverini G. Acetyl-L-carnitine supplementation differently influences nutrient partitioning, serum leptin concentration and skeletal muscle mitochondrial respiration in young and old rats. J Nutr 2002 Apr;132(4):636-42
2. Hongu N, Sachan DS. Carnitine and choline supplementation with exercise alter carnitine profiles, biochemical markers of fat metabolism and serum leptin concentration in healthy women. J Nutr 2003 Jan;133(1):84-9
3. Iyer RN, Khan AA, Gupta A, Vajifdar BU, Lokhandwala YY. L-carnitine moderately improves the exercise tolerance in chronic stable angina. J Assoc Physicians India 2000 Nov;48(11):1050-2 [abstract]
4. Loster H, Miehe K, Punzel M, Stiller O, Pankau H, Schauer J. Prolonged oral L-carnitine substitution increases bicycle ergometer performance in patients with severe, ischemically induced cardiac insufficiency. Cardiovasc Drugs Ther 1999 Nov;13(6):537-46 [abstract]
5. Sloan RS, Kastan B, Rice SI, Sallee CW, Yuenger NJ, Smith B, Ward RA, Brier ME, Golper TA. Quality of life during and between hemodialysis treatments: role of L-carnitine supplementation. Am J Kidney Dis 1998 Aug;32(2):265-72 [abstract]
6. Feinfeld DA, Kurian P, Cheng JT, Dilimetin G, Arriola MR, Ward L, Manis T, Carvounis CP. Effect of oral L-carnitine on serum myoglobin in hemodialysis patients. Ren Fail 1996 Jan;18(1):91-6 [abstract]
7. Watanabe S, Ajisaka R, Masuoka T, Yamanouchi T, Saitou T, Toyama M, Takeyasu N, Sakamoto K, Sugishita Y. Effects of L- and DL-carnitine on patients with impaired exercise tolerance. Jpn Heart J 1995 May;36(3):319-31 [abstract]
8. Volek JS, Kraemer WJ, Rubin MR, Gomez AL, Ratamess NA, Gaynor P. L-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress. Am J Physiol Endocrinol Metab 2002 Feb;282(2):E474-82
9. Beal MF. Bioenergetic approaches for neuroprotection in Parkinson's disease. Ann Neurol 2003;53 Suppl 3:S39-47; discussion S47-8
10. Montgomery SA, Thal LJ, Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. Int Clin Psychopharmacol 2003 Mar;18(2):61-71
11. Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A 2002 Feb 19;99(4):2356-61
12. Yasui F, Matsugo S, Ishibashi M, Kajita T, Ezashi Y, Oomura Y, Kojo S, Sasaki K. Effects of chronic acetyl-L-carnitine treatment on brain lipid hydroperoxide level and passive avoidance learning in senescence-accelerated mice. Neurosci Lett 2002 Dec 16;334(3):177-80 [abstract]
13. Liu J, Atamna H, Kuratsune H, Ames BN. Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann N Y Acad Sci 2002 Apr;959:133-66
14. De Angelis C, Scarfo C, Falcinelli M, Perna E, Reda E, Ramacci MT, Angelucci L. Acetyl-L-carnitine prevents age-dependent structural alterations in rat peripheral nerves and promotes regeneration following sciatic nerve injury in young and senescent rats. Exp Neurol 1994 Jul;128(1):103-14
15. Bertoni-Freddari C, Fattoretti P, Caselli U, Paoloni R. Acetylcarnitine modulation of the morphology of rat hippocampal synapses. Anal Quant Cytol Histol 1996 Aug;18(4):275-8 [abstract]
16. Rizos I. Three-year survival of patients with heart failure caused by dilated cardiomyopathy and L-carnitine administration. Am Heart J 2000 Feb;139(2 Pt 3):S120-3
17. Singh RB, Niaz MA, Agarwal P, Beegum R, Rastogi SS, Sachan DS. A randomised, double-blind, placebo-controlled trial of L-carnitine in suspected acute myocardial infarction. Postgrad Med J 1996 Jan;72(843):45-50 [abstract]
18. Ghidini O, Azzurro M, Vita G, Sartori G. Evaluation of the therapeutic efficacy of L-carnitine in congestive heart failure. Int J Clin Pharmacol Ther Toxicol 1988 Apr;26(4):217-20 [abstract]
19. Mondillo S, Faglia S, D'Aprile N, Mangiacotti L, Campolo MA, Agricola E, Palazzuoli V. [Therapy of arrhythmia induced by myocardial ischemia. Association of L-carnitine, propafenone and mexiletine]. Clin Ter 1995 Dec;146(12):769-74 [abstract]
20. Hagen TM, Ingersoll RT, Wehr CM, Lykkesfeldt J, Vinarsky V, Bartholomew JC, Song MH, Ames BN. Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. Proc Natl Acad Sci U S A. 1998 Aug 4; 95(16): 9562-6.
21. Basu S, Riserus U, Turpeinen A, Vessby B. Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity. Clin Sci (Lond). 2000 Dec;99(6):511-6.
22. Sen CK, Packer L. Thiol homeostasis and supplements in physical exercise. Am J Clin Nutr 2000 Aug;72(2 Suppl):653S-69S
23. Khanna S, Atalay M, Laaksonen DE, Gul M, Roy S, Sen CK. Alpha-lipoic acid supplementation: tissue glutathione homeostasis at rest and after exercise. J Appl Physiol 1999 Apr;86(4):1191-6
24. 12. El Midaoui A, de Champlain J. Prevention of hypertension, insulin resistance, and oxidative stress by alpha-lipoic acid. Hypertension 2002 Feb;39(2):303-7
25. Baydas G, Yilmaz O, Celik S, Yasar A, Gursu MF. Effects of certain micronutrients and melatonin on plasma lipid, lipid peroxidation, and homocysteine levels in rats. Arch Med Res 2002 Nov-Dec;33(6):515-9 [abstract]
26. Larsen TM, Toubro S, Astrup A. Efficacy and safety of dietary supplements containing conjugated linoleic acid (CLA) for the treatment of obesity-evidence from animal and human studies. J Lipid Res. 2003 Aug 16 [Epub ahead of print]. [medline]
27. Belury MA. Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action. Annu Rev Nutr. 2002;22:505-31. Epub 2002 Apr 04.
28. Kelly GS. Conjugated linoleic acid: a review. Altern Med Rev. 2001 Aug;6(4):367-82.
29. Kilian M, Mautsch I, Gregor JI, Heinichen D, Jacobi CA, Schimke I, Guski H, Muller JM, Wenger FA. Influence of conjugated and conventional linoleic acid on tumor growth and lipid peroxidation in pancreatic adenocarcinoma in hamster. Prostaglandins Leukot Essent Fatty Acids. 2003 Jul;69(1):67-72.
30. Transplantation. 2003 Dec 27; 76(12): 1681-6. L-carnitine ameliorates abnormal vulnerability of steatotic rat livers to cold ischemic preservation. Tolba RH, Putz U, Decker D, Dombrowski F, Lauschke H.
31. Mingrone G, Greco AV, Capristo E, Benedetti G, Giancaterini A, De Gaetano A, Gasbarrini G. L-carnitine improves glucose disposal in type 2 diabetic patients. J Am Coll Nutr. 1999 Feb; 18(1): 77-82.
32. Waltner-Law ME, Wang XL, Law BK, Hall RK, Nawano M, Granner DK. Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J Biol Chem. 2002 Sep 20; 277(38): 34933-40. Epub 2002 Jul 12.
33. Zempleni J, Trusty TA, Mock DM. Lipoic acid reduces the activities of biotin-dependent carboxylases in rat liver. J Nutr. 1997 Sep;127(9):1776-81.
34. Bender DA. Optimum nutrition: thiamin, biotin and pantothenate. Proc Nutr Soc. 1999 May;58(2):427-33.
35. Aust J Biol Sci. 1976 Dec; 29(5-6): 419-28. Fatty liver and kidney syndrome in chicks. I. Effect of biotin in diet. Pearson JA, Johnson AR, Hood RL, Fogerty AC.
36. Chantre P, Lairon D. Phytomedicine. Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity. 2002 Jan;9(1):3-8
37. Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr. 1999 Dec;70(6):1040-5
38. Dulloo AG, Seydoux J, Girardier L, Chantre P, Vandermander J. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disord. 2000 Feb;24(2):252-8 [abstract]
39. Nakachi K, Eguchi H, Imai K. Can teatime increase one's lifetime? Ageing Res Rev. 2003 Jan;2(1):1-10
40. Lee SR, Im KJ, Suh SI, Jung JG. Protective effect of green tea polyphenol (-)-epigallocatechin gallate and other antioxidants on lipid peroxidation in gerbil brain homogenates. Phytother Res. 2003 Mar;17(3):206-9
41. Sung H, Nah J, Chun S, Park H, Yang SE, Min WK. In vivo antioxidant effect of green tea. Eur J Clin Nutr. 2000 Jul;54(7):527-9 [abstract]
Current Reviews: 1
This product was added to our catalog on Friday 01 August, 2003.
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L-Carnitine
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