Keep fat off During the Holidays with Designer Supplements Glucophase XR and Scivation Sesamin!
K-R-ALA makes
Glucophase XR a powerful insulin mimetic which can reduce carb related obesity or insulin resistance in muscle cells. It has also been shown to increase activity in dead human beta cells (cells that produce insulin), improve insulin sensitivity and increases fatty acid oxidation (fat loss). Insulin is the most anabolic hormone in the human body, but it has its drawbacks. If your body doesn’t have enough insulin it can cause muscle wasting however, an abundance of insulin causes fat gain, especially in problem areas like the lower stomach, love handles, hips and butt.
Glucophase XR contains Quercetin and its analogs Q3D and Q4D which have been shown to increase the body’s use of carbohydrates by shuttling them into the muscle tissue and preventing the excess from reaching fat cells.
D-Biotin or Vitamin H has been shown to increase cAMP which in turn causes fatty acid oxidation and an increase in energy. D-Biotin also activates human insulin peptide 3, which plays a major role in the development of new muscle tissue. It also helps to enhance ATP synthesis.
Scivation Sesamin can help you burn fat and keep it off! Sesamin increases the expression of the mitochondrial enzyme carnitine palmitoyl transferase (CPT). CPT, the rate-limiting enzyme in beta-oxidation of fatty acids in skeletal muscle and liver cell mitochondria, is found on the outer membrane of mitochondria and carries fatty acids across the membrane into the mitochondria by binding to them. Increasing the expression of CPT will allow more fatty acids to be transported into the mitochondria where they can be oxidized (burned).
Fat can be oxidized in the mitochondria and the peroxisomes of cells, the majority of this oxidation occurring in skeletal muscle cells and the liver. PPARalpha activation by sesamin increases fat oxidation in mitochondria and peroxisomes by increasing the expression of enzymes involved in beta-oxidation of fatty acids.
Of vital importance, Sesamin increases the expression of the mitochondrial enzyme carnitine palmitoyl transferase (CPT). CPT, the rate-limiting enzyme in beta-oxidation of fatty acids in skeletal muscle and liver cell mitochondria, is found on the outer membrane of mitochondria and carries fatty acids across the membrane into the mitochondria by binding to them. Increasing the expression of CPT will allow more fatty acids to be transported into the mitochondria where they can be oxidized.
Sesamin’s ability to cause an increase in fatty acid oxidation in both the mitochondria and peroxisomes is important because mitochondria can only oxidize short-chain to long-chain-fatty-acids while peroxisomes can shorten fatty acids of all lengths, including very-long-chain-fatty-acids (VLCFA). As its name suggests, Peroxisome Proliferator-Activator Receptor cause the creation of additional peroxisomes. More peroxisomes means more fat can be oxidized.
PPARalpha activation also increases uncoupling-proteins (UCPs). UCPs decrease the efficiency of mitochondria, which means an increase in UCPs would increase the calories needed to produce the same amount of energy as before, this is known as “calorie wasting.” “Wasting” calories would lead to a greater caloric expenditure and therefore fat loss.
Through increasing the expression of the enzymes involved in beta-oxidation and increasing UCPs, PPARalpha activation by sesamin will increase the rate and capacity at which cells can burn fat.
Sesamin supplementation has also been shown to decrease lipogenesis (fat storage) by decreasing lipogenic enzymes in the liver. Sesamin has been shown to decrease lipogenic the gene expression of sterol regulatory element binding protein-1 (SREBP-1), acetyl-CoA carboxylase, and fatty acid synthase, among other lipogenic enzymes [10], which means less fat is esterifized in the liver and therefore less fat is stored in adipose tissue (fat cells). So Sesamin works in two ways to make you lean (and keep you lean): increasing fat oxidation and decreasing fat storage.
Get lean for the new year with this amazing stack at an amazing price!
